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Adderall, a prescription medication, is a combination of two stimulant drugs: amphetamine and dextroamphetamine. It is primarily used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Adderall works by increasing the levels of certain neurotransmitters in the brain, such as dopamine and norepinephrine, which help improve attention, focus, and impulse control in individuals with ADHD. Additionally, it promotes wakefulness in those suffering from narcolepsy. As a central nervous system stimulant, Adderall has been effective in managing these conditions, but it requires careful monitoring due to its potential for abuse and dependence.

Dosage Instructions for Adderall:

The dosage of Adderall (amphetamine and dextroamphetamine) varies depending on the condition being treated, the patient’s age, and their individual response to the medication. For the treatment of ADHD, the typical starting dose for children aged 6 to 12 is 5 mg once or twice daily, which may be increased by 5 mg increments at weekly intervals until the optimal response is achieved. For adolescents aged 13 to 17, the starting dose is usually 10 mg once daily, which can also be increased weekly. Adults with ADHD typically start with 20 mg per day.

For the treatment of narcolepsy, the usual starting dose for adults and children aged 12 and older is 10 mg daily, with possible increases of 10 mg increments at weekly intervals. Children aged 6 to 12 usually start with 5 mg daily.

Adderall is available in immediate-release (IR) tablets and extended-release (XR) capsules. The IR tablets are typically taken one to three times a day, with 4 to 6-hour intervals between doses. The XR capsules are usually taken once daily in the morning to provide all-day symptom control. It is important to take Adderall exactly as prescribed by a healthcare provider.

Patients should avoid taking Adderall late in the day to prevent insomnia. The medication can be taken with or without food, but taking it with food may help reduce stomach upset. It is crucial not to crush or chew the extended-release capsules, as this can release the drug all at once, increasing the risk of side effects. If a dose is missed, it should be taken as soon as remembered, but not too close to the next scheduled dose to avoid doubling up. Regular follow-up with a healthcare provider is essential to monitor the effectiveness and any potential side effects or need for dosage adjustments.

Primary Uses and Restrictions for Adderall:

Primary Uses:

1. Attention Deficit Hyperactivity Disorder (ADHD):
   • Improves attention span, focus, and impulse control in individuals with ADHD.
   • Reduces hyperactive and disruptive behaviors, enhancing overall functioning.
2. Narcolepsy:
   • Promotes wakefulness in patients suffering from narcolepsy.
   • Helps reduce excessive daytime sleepiness and sudden sleep attacks.

Restrictions for Adderall:

1. Cardiovascular Conditions:
   • Contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, or hyperthyroidism due to the risk of serious cardiovascular events.
2. Substance Abuse History:
   • Should not be used by individuals with a history of drug abuse, as Adderall has a high potential for abuse, dependence, and addiction.
3. Mental Health Conditions:
   • Use with caution in patients with a history of psychosis, bipolar disorder, or severe anxiety, as it can exacerbate these conditions.
4. Pregnancy and Breastfeeding:
   • Adderall is classified as a Pregnancy Category C drug. It should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. It is not recommended for use during breastfeeding as amphetamines are excreted in breast milk and can affect the nursing infant.
5. MAOI Use:
   • Contraindicated in patients currently using or having used monoamine oxidase inhibitors (MAOIs) within the past 14 days, as this can cause a hypertensive crisis.
6. Age Restrictions:
   • Safety and efficacy have not been established in children under 3 years of age for immediate-release tablets and under 6 years of age for extended-release capsules.

Contraindications for Adderall:

1. Cardiovascular Conditions: Adderall is contraindicated in patients with significant cardiovascular conditions, such as advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, or hyperthyroidism. The stimulant effects of Adderall can exacerbate these conditions, leading to serious cardiovascular events like heart attack or stroke.
2. History of Substance Abuse: Individuals with a history of substance abuse, including amphetamines or other stimulants, should not use Adderall due to its high potential for abuse, dependence, and addiction. Patients with a predisposition to substance abuse are at increased risk of misusing Adderall for non-medical purposes.
3. Mental Health Conditions: Adderall should be used with caution in patients with a history of psychosis, bipolar disorder, or severe anxiety. The medication can exacerbate symptoms of these conditions, leading to psychosis, mania, or panic attacks. Close monitoring is necessary when prescribing Adderall to patients with pre-existing mental health disorders.
4. Pregnancy and Breastfeeding: Adderall is classified as a Pregnancy Category C drug, meaning that its safety during pregnancy has not been established. It should only be used during pregnancy if the potential benefits outweigh the potential risks to the fetus. Additionally, Adderall is excreted in breast milk and can affect the nursing infant, so it is not recommended for use during breastfeeding.
5. MAOI Use: Concomitant use of Adderall with monoamine oxidase inhibitors (MAOIs) is contraindicated due to the risk of hypertensive crisis. MAOIs inhibit the breakdown of amphetamines, leading to increased blood levels and potentially dangerous interactions. A washout period of at least 14 days is recommended between discontinuation of MAOIs and initiation of Adderall therapy.